A desolvation barrier to hydrophobic cluster formation may contribute to the rate-limiting step in protein folding
نویسندگان
چکیده
منابع مشابه
A desolvation barrier to hydrophobic cluster formation may contribute to the rate-limiting step in protein folding.
To gain insight into the free energy changes accompanying protein hydrophobic core formation, we have used computer simulations to study the formation of small clusters of nonpolar solutes in water. A barrier to association is observed at the largest solute separation that does not allow substantial solvent penetration. The barrier reflects an effective increase in the size of the cavity occupi...
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ژورنال
عنوان ژورنال: Protein Science
سال: 1997
ISSN: 0961-8368
DOI: 10.1002/pro.5560060210